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KMID : 1146820190210020023
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Asian Journal of Kinesiology
2019 Volume.21 No. 2 p.23 ~ p.30
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Effects of Fermented Sea Tangle Supplementation on the Oxidative Stress and DNA Damage in Older Women
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Jeon Byeong-Hwan
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Abstract
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OBJECTIVES: The free radical theory of aging posits that a decrease in antioxidant capacity occurs in old age. This exposes the body to greater oxidative stress, which has been reported to have a causal effect on the aging process and development of disease. Sea tangle is a fermented food source shown to provide a reducing antioxidant effect.
METHODS: Forty senior women participated in a randomized, double-blind, and placebo-controlled study. Two groups were formed, one placebo (74.57 ± 5.69 yrs) and one FST (fermented sea tangle) group (72.35 ± 5.54 yrs), which received 1.5g/day of FST for 6 weeks.
RESULTS: Serum superoxide dismutase (SOD), glutathione peroxidase (GPX), glutathione reductase (GSR), thiobarbituric reactive species (TBARS) and 8-hydroxodeoxyguanosine (8-OHdG) levels were analyzed before and after the experimental period. FST supplementation significantly increased serum SOD and GSR levels. Whereas, levels of oxidative stress markers, TBARS and 8-OHdG were significantly decreased in comparison to those in the placebo group, after 6 weeks.
CONCLUSIONS: Our results suggest that FST can act as an effective exogenous antioxidant intervention against the dwindling efficiency of our biological defenses and/or increased intracellular reactive oxygen and DNA damage levels, associated with aging.
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KEYWORD
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8-Hydroxydeoxyguanosine(8-OHdG), Aging, Oxidative Stress, Sea Tangle
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